Wade, who has battled knee injuries, was held out for precautionary reasons and the Heat spread the scoring out to extend their winning streak to four games.
Chris Bosh led with 19 points, LeBron James scored 13 points, Ray Allen added 17 points off the bench, and Mario Chalmers dropped 14 as the Heat opened up a huge lead, mainly by forcing the Hawks into more than 20 turnovers.
“I give Miami and their defense a lot of credit. Their activity can make it difficult on you offensively,” Hawks head coach Mike Budenholzer said.
Atlanta was led by Mike Scott with 15 points, Al Horford had 12 points, seven rebounds and seven turnovers and Kyle Korver extended his streak to 84 consecutive games with a 3-pointer.
However, It was 78-68 going into the fourth quarter and the Hawks never got closer than nine after that.
The Heat are at Orlando on Wednesday night and the Hawks start a home-and-home against the Pistons on Wednesday in Atlanta.