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Studies Link Early Use of Antibiotics to Obesity

The use of antibiotics in young children might lead to a higher risk of obesity, and two new studies, one on mice and one on humans, conclude that changes of the intestinal bacteria caused by antibiotics could be responsible.

Taken together, the New York University researchers conclude that it might be necessary to broaden our concept of the causes of obesity and urge more caution in using antibiotics. Both studies focus on the early age, because that is when obesity begins, the scientists say.

The first study, published Wednesday in Nature, used mice to investigate the effects of low doses of antibiotic treatment. The researchers, led by Martin Blaser, thereby mimicked the treatment farm animals have been receiving in the United States in recent decades. Since the 1950s, low doses of antibiotics have been widely used as growth promoters in animals, reportedly increasing their size of by up to 10 percent.

“People used antibiotics to treat infections, but then they were surprised that even in the absence of disease, this led to bigger animals,” said scientist Didier Raoult, who was not connected to the studies.

Aiming to explain these observations, Blaser’s team treated young mice with low doses of antibiotics and found that while the treated mice did not become larger overall, they were, in fact, more obese.

The researchers suspected that changes in the intestine bacteria were responsible. They surveyed the bacteria using genetic methods and found that while treated and untreated mice had a similar total count of bacteria species, their compositions seemed to diverge. Some species of bacteria, previously shown to be associated with obesity in mice, were found at a higher concentration.

The scientists then did a genetic analysis of the bacteria’s metabolism and found that some genes responsible for fat synthesis showed a higher activity in the treated mice…

Read more: Hristio Boytchev, Washington Post


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